Benzodiazepine Equivalence
Enter a benzodiazepine and dose to obtain diazepam equivalents and convert to another benzodiazepine. Intended for guidance during cross-tapering or substitution therapy.
Conversion Result
Diazepam equivalent
10.0 mg/day
Source: 1.0 mg/day Alprazolam (Xanax). Half-life: 12–15 h.
Target equivalent dose
10.0 mg/day
Target medication: Diazepam (Valium). Half-life: 20–80 h (active metabolites longer).
How to Use This Calculator
Identify current benzodiazepine
Input the total daily dose (scheduled + PRN) to find its diazepam equivalent.
Select target medication
Choose the benzodiazepine you plan to switch to; the calculator shows the equivalent daily dose.
Plan a taper
Use the diazepam equivalent to design gradual dose reductions, minimizing withdrawal symptoms.
Formula
Diazepam equivalent (mg) = Source dose (mg) × diazepam-equivalent factor.
Equivalence factors adapted from Ashton Manual tables, NICE guidelines, and BNF recommendations.
Frequently Asked Questions
Why convert to diazepam?
Diazepam has a long half-life and active metabolites, making it suitable for tapering and withdrawal management.
Are conversions exact?
No—interpatient variability is high. Use these conversions as starting points and adjust clinically.
How fast can I taper?
Reduce total benzodiazepine dose by 5–10% every 1–2 weeks; slower tapers may be needed after long-term use.
What about renal/hepatic impairment?
Select agents with simpler metabolism (lorazepam, oxazepam) in hepatic dysfunction; adjust dosing accordingly.
Can I apply this to IV dosing?
These are oral dose equivalents. IV dosing requires separate conversion references.