Carboplatin (Calvert Formula)
Determine carboplatin dose based on target AUC and renal function. Supports adult and pediatric oncology dosing with optional body surface area normalization.
Common AUC values: 4–6 (single-agent), 2–5 (combo regimens).
Use measured GFR or Cockcroft-Gault creatinine clearance.
Dose Result
Carboplatin dose
525 mg
Dose = 5 × (80 + 25).
How to Use This Calculator
Determine target AUC
Select regimen-specific AUC (e.g., AUC 5 for single-agent, AUC 6 for high-dose).
Obtain renal function
Use measured GFR, nuclear medicine clearance, or Cockcroft-Gault creatinine clearance.
Consider BSA
Normalize to mg/m² if comparing with prior regimens or referencing literature.
Formula
Calvert formula: Dose (mg) = Target AUC × (GFR + 25).
Calvert AH et al., J Clin Oncol.1989; institutional oncology dosing guidelines.
Frequently Asked Questions
When should I cap GFR?
Many centers cap GFR at 125 mL/min (or 100) to avoid excessive dosing in patients with excellent renal function.
What if GFR is extremely low?
For GFR <15 mL/min or dialysis patients, consult oncology pharmacy; alternative regimens may be preferred.
Do I use actual, ideal, or adjusted body weight?
For Cockcroft-Gault, use institutional policy (often adjusted body weight if BMI >25).
How do I round the dose?
Round to the nearest 10 mg or vial size per pharmacy guidelines; record the calculated (pre-rounding) dose.
Is BSA dosing still used?
Calvert formula replaces BSA-based dosing for carboplatin; BSA output is for reference only.