FFP Dosing Estimator
Enter patient weight and the desired percent correction of coagulation factors to calculate FFP volume and units required.
Typical correction aims for 15–20% volume replacement.
40 mL/kg default; adjust for pediatrics or special populations.
Estimated plasma volume
2800 mL
FFP volume needed
420 mL
Number of 250 mL units
2
How to Use This Calculator
Assess the indication
Confirm FFP is indicated (active bleeding or invasive procedure with significant coagulopathy). Avoid prophylactic use without evidence.
Enter patient-specific parameters
Provide weight and desired correction percentage. Plasma volume defaults to 40 mL/kg (adjust for pediatrics, pregnancy, or obesity).
Review calculated FFP units
Use the calculated mL and unit count to order blood products. Recheck INR/PT after transfusion and monitor for volume overload.
Formula
Plasma volume (mL) = Weight (kg) × Plasma volume per kg (mL/kg)
Required FFP volume = Plasma volume × Target correction (%) ÷ 100
FFP units = Required volume ÷ Unit volume (250 mL)
Full Description
Fresh frozen plasma transfusion replaces multiple coagulation factors, particularly in rapid-onset coagulopathies. Typical dosing is 10–15 mL/kg, but exact volume depends on desired correction and patient plasma volume. This calculator supports individualized dosing while emphasizing continued lab monitoring, evaluation for targeted factor replacements (e.g., PCC/cryoprecipitate), and vigilance for transfusion reactions or volume overload.
Frequently Asked Questions
What if the patient is obese?
Consider using adjusted body weight or lower plasma volume per kg to avoid overestimation and volume overload.
How soon should INR be rechecked?
Repeat PT/INR 30–60 minutes after completion of FFP infusion to evaluate response.
Are there alternatives to FFP?
Prothrombin complex concentrates or specific factor concentrates can be used depending on the coagulation deficit and urgency.
Can I use this for TTP or volume expansion?
No. TTP requires plasma exchange protocols. FFP should not be used solely for volume expansion.