Isotretinoin Cumulative Dosing
Calculate progress toward cumulative isotretinoin targets (typically 120–150 mg/kg) to minimize relapse risk.
Common daily dose = 0.5–1 mg/kg/day (split BID).
Guideline range: 120–150 mg/kg. Higher for severe/resistant cases.
Dosing Status
Cumulative dose
1200 mg
17.1 mg/kg achieved (12.2% of target).
Remaining
8600 mg remaining
Projected 215.0 days left at 40 mg/day.
How to Use This Calculator
Confirm patient weight
Base cumulative goal on stable weight at therapy initiation.
Track daily dose and days
Include any dose adjustments in the average daily amount.
Monitor cumulative progress
Aim for 120–150 mg/kg cumulative exposure to reduce relapse risk.
Formula
Cumulative target (mg) = weight (kg) × target (mg/kg).
Guided by American Academy of Dermatology acne guidelines.
Frequently Asked Questions
What if the patient can’t tolerate the dose?
Reduce daily dose and extend duration to reach cumulative goal. Document cumulative total carefully.
Are higher cumulative doses better?
Higher than 150 mg/kg does not clearly reduce relapse and increases adverse effects.
How to handle missed doses?
Do not double up. The cumulative calculator reflects actual days taken.
Is dose adjustment needed for obesity?
Use actual body weight but consider max daily dose 120 mg/day per label; adjust with dermatologist oversight.
What labs are monitored?
Baseline and periodic lipids, liver enzymes, pregnancy tests (iPLEDGE). Monitor mood changes.